Nature Communications (Jan 2021)

SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation

  • Yi Tian,
  • Chao Han,
  • Zhiyuan Wei,
  • Hui Dong,
  • Xiaohe Shen,
  • Yiqiang Cui,
  • Xiaolan Fu,
  • Zhiqiang Tian,
  • Shufeng Wang,
  • Jian Zhou,
  • Di Yang,
  • Yi Sun,
  • Jizhao Yuan,
  • Bing Ni,
  • Yuzhang Wu

DOI
https://doi.org/10.1038/s41467-020-20786-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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T helper 17 (Th17) cells are important mediators of inflammatory diseases and fungal infection protection, and are critically regulated by the transcription factor (TF), RORγt. Here the authors identify a new enhancer for RORγt, RORCE2, which synergizes with another TF, Sox5, for binding with RORγt promoter and thereby modulation of RORγt expression.