Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution

Yinghua Li; Bo Li; Wei Li; Yuan Wang; Seçkin Akgül; Daniel M. Treisman; Kevin A. Heist; Brianna R. Pierce; Benjamin Hoff; Cheng-Ying Ho; David O. Ferguson; Alnawaz Rehemtulla; Siyuan Zheng; Brian D. Ross; Jun Z. Li; Yuan Zhu

doi:10.1038/s41467-020-17382-3

Nature Communications (Jul 2020)

Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution

Yinghua Li,
Bo Li,
Wei Li,
Yuan Wang,
Seçkin Akgül,
Daniel M. Treisman,
Kevin A. Heist,
Brianna R. Pierce,
Benjamin Hoff,
Cheng-Ying Ho,
David O. Ferguson,
Alnawaz Rehemtulla,
Siyuan Zheng,
Brian D. Ross,
Jun Z. Li,
Yuan Zhu

Affiliations

Yinghua Li: Gilbert Family Neurofibromatosis Institute, Children’s National Hospital
Bo Li: Department of Human Genetics, University of Michigan Medical School
Wei Li: Center for Genetic Medicine Research, Children’s National Hospital
Yuan Wang: Gilbert Family Neurofibromatosis Institute, Children’s National Hospital
Seçkin Akgül: Gilbert Family Neurofibromatosis Institute, Children’s National Hospital
Daniel M. Treisman: Gilbert Family Neurofibromatosis Institute, Children’s National Hospital
Kevin A. Heist: Department of Radiology, University of Michigan Medical School
Brianna R. Pierce: Gilbert Family Neurofibromatosis Institute, Children’s National Hospital
Benjamin Hoff: Department of Radiology, University of Michigan Medical School
Cheng-Ying Ho: Center for Genetic Medicine Research, Children’s National Hospital
David O. Ferguson: Department of Pathology, University of Michigan Medical School
Alnawaz Rehemtulla: Department of Radiation Oncology, University of Michigan Medical School
Siyuan Zheng: Greehey Children’s Cancer Research Institute, The University of Texas Health Science Center at San Antonio
Brian D. Ross: Department of Radiology, University of Michigan Medical School
Jun Z. Li: Department of Human Genetics, University of Michigan Medical School
Yuan Zhu: Gilbert Family Neurofibromatosis Institute, Children’s National Hospital

DOI: https://doi.org/10.1038/s41467-020-17382-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 19

Abstract

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Recent studies suggest spatial segregation of tumor initiation and manifestation in IDH-WT glioblastomas. Here, the authors use serial MRI/3D-reconstruction, whole-genome sequencing and spectral karyotyping-based single-cell phylogenetic tree building to establish this unique evolutionary mode in a murine model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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