Infection and Drug Resistance (Oct 2023)

The Biological and Regulatory Role of Type VI Secretion System of Klebsiella pneumoniae

  • Liu W,
  • Li M,
  • Cao S,
  • Ishaq HM,
  • Zhao H,
  • Yang F,
  • Liu L

Journal volume & issue
Vol. Volume 16
pp. 6911 – 6922


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Wenke Liu,1,* Min Li,1,* Shiwen Cao,1 Hafiz Muhammad Ishaq,2 Huajie Zhao,1 Fan Yang,1 Liang Liu1 1Department of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, People’s Republic of China; 2Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan*These authors contributed equally to this workCorrespondence: Liang Liu, Email [email protected]: Bacteria communicate with their surroundings through diverse secretory systems, and the recently discovered Type VI Secretion System (T6SS) has gained significant attention. Klebsiella pneumoniae (K. pneumoniae), an opportunistic pathogen known for causing severe infections in both hospital and animal settings, possesses this intriguing T6SS. This system equips K. pneumoniae with a formidable armory of protein-based weaponry, enabling the delivery of toxins into neighboring cells, thus granting a substantial competitive advantage. Remarkably, the T6SS has also been associated with K. pneumoniae’s ability to form biofilms and acquire resistance against antibiotics. However, the precise effects of the T6SS on K. pneumoniae’s functions remain inadequately studied, despite research efforts to understand the intricacies of these mechanisms. This comprehensive review aims to provide an overview of the current knowledge regarding the biological functions and regulatory mechanisms of the T6SS in K. pneumoniae.Keywords: Klebsiella pneumoniae, T6SS, competition, drug resistance, virulence