Normal platelet mitochondrial complex I activity in Huntington’s Disease

William J. Powers; Richard H. Haas; Thuy Le; Tom O. Videen; Tamara Hershey; Lori McGee-Minnich; Joel S. Perlmutter

Neurobiology of Disease (Jul 2007)

Normal platelet mitochondrial complex I activity in Huntington’s Disease

William J. Powers,
Richard H. Haas,
Thuy Le,
Tom O. Videen,
Tamara Hershey,
Lori McGee-Minnich,
Joel S. Perlmutter

Affiliations

William J. Powers: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA
Richard H. Haas: Department of Neurosciences, University of California, San Diego, CA, USA; Department of Pediatrics, University of California, San Diego, CA, USA
Thuy Le: Department of Neurosciences, University of California, San Diego, CA, USA
Tom O. Videen: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA
Tamara Hershey: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
Lori McGee-Minnich: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
Joel S. Perlmutter: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO, USA; Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA; Corresponding author. Campus Box 8225, 4525 Scott Avenue, Washington University School of Medicine, St. Louis, MO 63110, USA. Fax: +1 314 362 0168.

Journal volume & issue: Vol. 27, no. 1
pp. 99 – 101

Abstract

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Two small case series of platelet mitochondrial complex I activity assays in Huntington’s Disease (HD) report discrepant results. We measured platelet complex I and complex I/III activity in 21 subjects with early gene-positive HD and 14 age-matched controls. The 21 participants with HD that we studied are greater than the total of 16 in the two previously published of platelet ETS activity in HD. Reductions ?>>10% were excluded with 80% confidence. A systemic defect in complex I activity is not present in early HD when striatal neuronal degeneration is already present.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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