Nature Communications (Jul 2021)

Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition

  • Na Zhao,
  • Reid T. Powell,
  • Xueying Yuan,
  • Goeun Bae,
  • Kevin P. Roarty,
  • Fabio Stossi,
  • Martina Strempfl,
  • Michael J. Toneff,
  • Hannah L. Johnson,
  • Sendurai A. Mani,
  • Philip Jones,
  • Clifford C. Stephan,
  • Jeffrey M. Rosen

Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13


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The epithelial-mesenchymal transition (EMT) has been implicated in stem cell properties and therapeutic resistance in cancer. Here, the authors show organoids derived from mesenchymal breast cancers exhibit a spikey structure which can be reverted and exploited for screening drugs that reverse EMT.