Онкогематология (Jul 2014)

Detection of 11q23 (MLL) rearrangements in infant acute lymphoblastic leukemia

  • G. A. Tsaur,
  • A. M. Popov,
  • O. V. Aleynikova,
  • E. G. Boychenko,
  • T. Yu. Verzhbitskaya,
  • E. V. Volochnik,
  • A. S. Ivanova,
  • O. V. Kalennik,
  • S. Yu. Kovalev,
  • K. L. Kondtratchik,
  • A. M. Kustanovich,
  • E. S. Lapotentova,
  • D. V. Litvinov,
  • I. S. Martynkevich,
  • N. V. Myakova,
  • T. V. Nasedkina,
  • V. A. Ovsepyan,
  • Yu. V. Olshanskaya,
  • O. M. Plehanova,
  • A. V. Popa,
  • T. O. Riger,
  • L. I. Savelyev,
  • O. V. Streneva,
  • M. V. Strigaleva,
  • I. V. Shmunk,
  • E. V. Shorikov,
  • L. G. Fechina

DOI
https://doi.org/10.17650/1818-8346-2011-6-3-57-64
Journal volume & issue
Vol. 6, no. 3
pp. 57 – 64

Abstract

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117 cases of infant acute lymphoblastic leukemia without Down syndrome (aged from 1 to 365 days) were included in the current study.Rearrangements of 11q23 (MLL) were revealed in 74 (63.2 %) patients. Among this group the most common rearrangement was t(4;11) q21;q23)/MLL-AF4 detected in 63.5 % cases, less frequently was found t(11;19)(q23;p13)/MLL-MLLT1 (in 18.9 % cases), t(10;11) p12;q23)/MLL-MLLT10 and t(1;11)(p32;q23)/ML L-EPS15 (each one in 6.8 %), t(9;11)(p22;q23)/MLL-MLLT3 in 2.7 %. Children under 6 months of age had significantly higher incidence of 11q23 (ML L) rearrangements in comparison with infants olde r than 6 months (84.0 % vs. 47.8 %, p < 0.001). P atients with translocations 11q23 (ML L) more frequently had BI-A LL and less frequently BII-ALL than children without these rearrangements (p < 0.001 f or both). Fusion gene transcript w as sequenced in 26 ML Lrearranged cases. Depending on breakpoint position within ML L and partner genes we detected 7 differ ent types of ML L-AF4 fusion gene transcript, 3 types of MLL-MLLT1, 2 types of MLL-EPS15. The most common fusion site within MLL gene was exon 11, detected in 14 (53.8 %) patients.

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