Nature Communications (Apr 2016)

Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration

  • Nathan D. Jones,
  • Miguel A. Lopez Jr,
  • Jeungphill Hanne,
  • Mitchell B. Peake,
  • Jong-Bong Lee,
  • Richard Fishel,
  • Kristine E. Yoder

DOI
https://doi.org/10.1038/ncomms11409
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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Retroviral Integration into the host DNA is a rare event with evidence suggesting that it relies on DNA topology and sequence. Here the authors present single molecule evidence that shows the retroviral integration machinery vigorously scans the target DNA by 1D-diffusion but infrequently integrates.