Journal of Ophthalmic & Vision Research (Jan 2018)

Regression of giant olfactory groove meningioma and complete visual acuity recovery after discontinuation of cyproterone acetate

  • Anne Laure Bernat,
  • Sophie Bonnin,
  • Moujahed Labidi,
  • Nouman Aldahak,
  • Damien Bresson,
  • Schahrazed Bouazza,
  • Sebastien Froelich

DOI
https://doi.org/10.4103/jovr.jovr_21_17
Journal volume & issue
Vol. 13, no. 3
pp. 355 – 358

Abstract

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Purpose: To report on the medical management of meningioma with compression of the optic chiasm associated with the use of cyproterone acetate (CA). Case Report: A 65-year-old woman who was being treated with CA presented with a recent decrease in visual function, leading to discovery of a giant olfactory groove meningioma with compression of the optic chiasm. CA was discontinued immediately, and her visual function improved dramatically. At 13 months, in addition to a significant improvement in visual and neurocognitive symptoms, the tumor volume was reduced by 50%. Conclusion: In meningiomas associated with CA, treatment cessation may result in prompt improvement in symptoms and a reduction in tumor volume, even if the tumor is large and causing neurologic impairments.

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