Smoking effects on renal function in young men with early stages of essential arterial hypertension

Abstract

Aim. To study smoking effects on renal damage progression in young men with early stages of essential arterial hypertension (AH). Material and methods. The study included 118 AH men aged 18–35 years (mean age 22,1±4,54 years). AH duration varied from 1 to 8 years (mean duration 4,14±2,1 years). Self-reported smoking prevalence (>1 cigarette per day) was 52 % (n=61). Smokers and non-smokers were comparable by age, AH duration, body mass index, and other cardiovascular risk factors. All participants underwent dynamic renal angioscintigraphy, with intravenous Tc99m DTPA administration and glomerular filtration rate (GFR) assessment. Results. According to dynamic renal angioscintigraphy data, GFR levels differed significantly in smokers and non-smokers with Stage I AH. In Stage II and III AH, the difference was not statistically significant. Conclusion. Smoking facilitated hyperfiltration progression in Stage I AH young men, comparing to non-smoking patients.

Keywords

• arterial hypertension
• men
• target organs
• risk factors
• smoking