Clinical case of combined infectious pathology (Varicella-Zoster and hantaan hemorrhagic fever) in patient with disseminated psoriasis

Abstract

The article describes in detail the clinical case of a severe course of a combined viral disease (Varicella-Zoster, Hantaan Hemorrhagic Fever), complicated by bilateral interstitial pneumonia, cerebral edema, and disseminated vascular coagulation syndrome, developed in an immunocompromised patient during the treatment period of exacerbation of a background disease (plaque psoriasis, progressive stage) with a cytostatic drug. The role of the main and associated diseases (pathogenetic mechanisms of comorbidity), specificly, hantavirus infection and psoriasis, as co-factors in the formation of an unfavourable course of varicella-zoster in an adult, is discussed. An example of an individual approach to the patient, a comprehensive diagnosis and rational treatment that contributed to a favorable outcome of the disease is given.

Keywords

• varicella-zoster
• hantaan hemorrhagic fever
• psoriasis
• pneumonia
• comorbid disease