Progress on the role of MBD2 pathway in severe asthma

Abstract

Severe asthma is a chronic inflammatory disease that is not sensitive to glucocorticoid treatment. In the pathogenesis of severe asthma, T helper cell 17(Th17) and interleukin 17 (IL-17) play an important role, mainly by aggregating the infiltration of neutrophil to aggravate the severity of asthma. Methyl-CpG-binding protein 2 (MBD2) plays an important role in the differentiation of Th17 cells from naive CD4+T cells,positively regulate Th17 differentiation and IL-17 expression. MBD2 binds to the CpG islands in the promoter region of interferon regulatory factor 4 (IRF4), suppressor of cytokine signaling 3 (SOCS3), hypoxia-inducible factor-1α (HIF-1α) and misshapen like kinase 1(MINK1), which leads to methylation, regulates the differentiation of Th17 cells, and participates in the pathogenesis of severe asthma.

Keywords

• severe asthma|methyl-cpg binding domain protein 2(mbd2)|t helper 17 cells