Discordance for Cri du Chat Syndrome in a dichorionic–diamniotic twin pregnancy

Abstract

We report on the prenatal diagnosis through array CGH of a dichorionic–diamniotic (DC/DA) twins discordant for Cri du Chat Syndrome. Structural anomalies on one of the twins lead to amniotic fluid sampling, which revealed a partial deletion on the short arm of the chromosome 5. Selective feticide of the affected twin was performed at 34 + 1 weeks' and elective Cesarean section at 37 + 2 weeks. Postnatal cytogenetic analysis confirmed pre-natal genetic findings. Keywords: Cri du Chat, Léjéune, 5p translocation, Selective termination