Nature Communications (Mar 2021)
Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling
- Ismael A. Vergara,
- Christopher P. Mintoff,
- Shahneen Sandhu,
- Lachlan McIntosh,
- Richard J. Young,
- Stephen Q. Wong,
- Andrew Colebatch,
- Daniel L. Cameron,
- Julia Lai Kwon,
- Rory Wolfe,
- Angela Peng,
- Jason Ellul,
- Xuelin Dou,
- Clare Fedele,
- Samantha Boyle,
- Gisela Mir Arnau,
- Jeanette Raleigh,
- Athena Hatzimihalis,
- Pacman Szeto,
- Jennifer Mooi,
- Daniel S. Widmer,
- Phil F. Cheng,
- Valerie Amann,
- Reinhard Dummer,
- Nicholas Hayward,
- James Wilmott,
- Richard A. Scolyer,
- Raymond J. Cho,
- David Bowtell,
- Heather Thorne,
- Kathryn Alsop,
- Stephen Cordner,
- Noel Woodford,
- Jodie Leditschke,
- Patricia O’Brien,
- Sarah-Jane Dawson,
- Grant A. McArthur,
- Graham J. Mann,
- Mitchell P. Levesque,
- Anthony T. Papenfuss,
- Mark Shackleton
Affiliations
- Ismael A. Vergara
- Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research
- Christopher P. Mintoff
- Peter MacCallum Cancer Centre
- Shahneen Sandhu
- Peter MacCallum Cancer Centre
- Lachlan McIntosh
- Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research
- Richard J. Young
- Peter MacCallum Cancer Centre
- Stephen Q. Wong
- Peter MacCallum Cancer Centre
- Andrew Colebatch
- Peter MacCallum Cancer Centre
- Daniel L. Cameron
- Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research
- Julia Lai Kwon
- Peter MacCallum Cancer Centre
- Rory Wolfe
- School of Public Health and Preventive Medicine, Monash University
- Angela Peng
- Peter MacCallum Cancer Centre
- Jason Ellul
- Peter MacCallum Cancer Centre
- Xuelin Dou
- Peter MacCallum Cancer Centre
- Clare Fedele
- Peter MacCallum Cancer Centre
- Samantha Boyle
- Peter MacCallum Cancer Centre
- Gisela Mir Arnau
- Peter MacCallum Cancer Centre
- Jeanette Raleigh
- Peter MacCallum Cancer Centre
- Athena Hatzimihalis
- Peter MacCallum Cancer Centre
- Pacman Szeto
- Peter MacCallum Cancer Centre
- Jennifer Mooi
- Peter MacCallum Cancer Centre
- Daniel S. Widmer
- Department of Dermatology, University of Zürich Hospital
- Phil F. Cheng
- Department of Dermatology, University of Zürich Hospital
- Valerie Amann
- Department of Dermatology, University of Zürich Hospital
- Reinhard Dummer
- Department of Dermatology, University of Zürich Hospital
- Nicholas Hayward
- Melanoma Institute of Australia
- James Wilmott
- Melanoma Institute of Australia
- Richard A. Scolyer
- Melanoma Institute of Australia
- Raymond J. Cho
- Department of Dermatology, University of California
- David Bowtell
- Peter MacCallum Cancer Centre
- Heather Thorne
- Peter MacCallum Cancer Centre
- Kathryn Alsop
- Peter MacCallum Cancer Centre
- Stephen Cordner
- The Victorian Institute of Forensic Medicine
- Noel Woodford
- The Victorian Institute of Forensic Medicine
- Jodie Leditschke
- The Victorian Institute of Forensic Medicine
- Patricia O’Brien
- The Victorian Institute of Forensic Medicine
- Sarah-Jane Dawson
- Peter MacCallum Cancer Centre
- Grant A. McArthur
- Peter MacCallum Cancer Centre
- Graham J. Mann
- Melanoma Institute of Australia
- Mitchell P. Levesque
- Department of Dermatology, University of Zürich Hospital
- Anthony T. Papenfuss
- Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research
- Mark Shackleton
- Peter MacCallum Cancer Centre
- DOI
- https://doi.org/10.1038/s41467-021-21576-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
The genetic changes that occur in late stage metastatic melanoma are not well delineated. Here, the authors use rapid autopsy samples from metastatic melanoma patients and show that the late stage in the disease is characterised by whole genome doubling and aneuploidy.
