Snail1: A Transcriptional Factor Controlled at Multiple Levels

Abstract

Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors. In this review, we describe the different elements that control Snail1 expression and its activity both as transcriptional repressor or activator.

Keywords

• Snail1
• transcriptional factor
• Epithelial to mesenchymal transition (EMT)
• tumor invasion
• drug resistance