Nature Communications (Jan 2018)
∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
- Hamish Campbell,
- Nicholas Fleming,
- Imogen Roth,
- Sunali Mehta,
- Anna Wiles,
- Gail Williams,
- Claire Vennin,
- Nikola Arsic,
- Ashleigh Parkin,
- Marina Pajic,
- Fran Munro,
- Les McNoe,
- Michael Black,
- John McCall,
- Tania L. Slatter,
- Paul Timpson,
- Roger Reddel,
- Pierre Roux,
- Cristin Print,
- Margaret A. Baird,
- Antony W. Braithwaite
Affiliations
- Hamish Campbell
- Children’s Medical Research Institute, University of Sydney
- Nicholas Fleming
- Department of Pathology, Dunedin School of Medicine, University of Otago
- Imogen Roth
- Department of Pathology, Dunedin School of Medicine, University of Otago
- Sunali Mehta
- Department of Pathology, Dunedin School of Medicine, University of Otago
- Anna Wiles
- Department of Pathology, Dunedin School of Medicine, University of Otago
- Gail Williams
- Department of Pathology, Dunedin School of Medicine, University of Otago
- Claire Vennin
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Nikola Arsic
- CNRS, Centre de Recherche de Biochimie Macromoléculaire de Montpellier
- Ashleigh Parkin
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Marina Pajic
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Fran Munro
- Department of Surgical Sciences, Dunedin School of Medicine, University of Otago
- Les McNoe
- Department of Biochemistry, School of Biomedical Sciences, University of Otago
- Michael Black
- Department of Biochemistry, School of Biomedical Sciences, University of Otago
- John McCall
- Department of Surgical Sciences, Dunedin School of Medicine, University of Otago
- Tania L. Slatter
- Department of Pathology, Dunedin School of Medicine, University of Otago
- Paul Timpson
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Roger Reddel
- Children’s Medical Research Institute, University of Sydney
- Pierre Roux
- CNRS, Centre de Recherche de Biochimie Macromoléculaire de Montpellier
- Cristin Print
- Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, c/o The University of Auckland
- Margaret A. Baird
- Department of Pathology, Dunedin School of Medicine, University of Otago
- Antony W. Braithwaite
- Children’s Medical Research Institute, University of Sydney
- DOI
- https://doi.org/10.1038/s41467-017-02408-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Aberrant expression of the Δ133p53 isoform is linked to many cancers. Here, the authors utilise a model of the Δ133p53 isoform that is prone to tumours and inflammation, showing that Δ133p53 promotes tumour cell invasion by activation of the JAK-STAT and RhoA-ROCK pathways in an IL-6 dependent manner.
