Genetic risk model for in-stent restenosis of second-and third-generation drug-eluting stents
Yen-Wen Liu,
Mu-Shiang Huang,
Ling-Wei Hsu,
Hsien-Yuan Chang,
Cheng-Han Lee,
Chi-Ying Lee,
Dao-Peng Chen,
Yi-Heng Li,
Ting-Hsin Chao,
Pei-Fang Su,
Meng-Ru Shen,
Ping-Yen Liu
Affiliations
Yen-Wen Liu
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road North District, Tainan 704, Taiwan
Mu-Shiang Huang
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Ling-Wei Hsu
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road North District, Tainan 704, Taiwan
Hsien-Yuan Chang
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road North District, Tainan 704, Taiwan
Cheng-Han Lee
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Chi-Ying Lee
KimForest Enterprise Co., Ltd., New Taipei City 221, Taiwan
Dao-Peng Chen
KimForest Enterprise Co., Ltd., New Taipei City 221, Taiwan
Yi-Heng Li
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Ting-Hsin Chao
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Pei-Fang Su
Department of Statistics, National Cheng Kung University, Tainan 704, Taiwan
Meng-Ru Shen
Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Ping-Yen Liu
Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road North District, Tainan 704, Taiwan; Corresponding author
Summary: The new generation, i.e., second- and third-generation, drug-eluting stents (DESs) remain a risk of in-stent restenosis (ISR). We evaluated the power of a genetic risk score (GRS) model to identify high-risk populations for new generation DES ISR. We enrolled patients with coronary artery disease (CAD) treated with new generations DESs by a single-center cohort study in Taiwan and evaluated their genetic profile. After propensity score matching, there were 343 patients and 153 patients in the derivation and validation cohorts, respectively. Five selected single-nucleotide polymorphisms (SNPs), i.e., SNPs in CAMLG, GALNT2, C11orf84, THOC5, and SAMD11, were included to calculate the GRS for new generation DES ISR. In the derivation and the validation cohorts, patients with a GRS greater than or equal to 3 had significantly higher new generation DES ISR rates. We provide biological information for interventional cardiologists prior to percutaneous coronary intervention by specific five SNP-derived GRS.
