Nature Communications (Jun 2017)
Structural and regulatory diversity shape HLA-C protein expression levels
- Gurman Kaur,
- Stephanie Gras,
- Jesse I. Mobbs,
- Julian P. Vivian,
- Adrian Cortes,
- Thomas Barber,
- Subita Balaram Kuttikkatte,
- Lise Torp Jensen,
- Kathrine E. Attfield,
- Calliope A. Dendrou,
- Mary Carrington,
- Gil McVean,
- Anthony W. Purcell,
- Jamie Rossjohn,
- Lars Fugger
Affiliations
- Gurman Kaur
- MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Stephanie Gras
- Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Jesse I. Mobbs
- Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Julian P. Vivian
- Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Adrian Cortes
- Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, Oxford Centre for Neuroinflammation, John Radcliffe Hospital, University of Oxford
- Thomas Barber
- Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, Oxford Centre for Neuroinflammation, John Radcliffe Hospital, University of Oxford
- Subita Balaram Kuttikkatte
- MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Lise Torp Jensen
- Department of Clinical Medicine, Aarhus University Hospital
- Kathrine E. Attfield
- MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Calliope A. Dendrou
- Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, Oxford Centre for Neuroinflammation, John Radcliffe Hospital, University of Oxford
- Mary Carrington
- Cancer and Inflammation Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research
- Gil McVean
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Anthony W. Purcell
- Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Jamie Rossjohn
- Infection and Immunity Program and the Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Lars Fugger
- MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- DOI
- https://doi.org/10.1038/ncomms15924
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
HLA-C expression levels correlate with immune responses to pathogens and autoimmunity, and vary in an allele-specific manner across individuals. Here the authors identify factors that drive differential expression of HLA-C allomorphs at the cell surface, and influence the structure of the peptide-binding cleft and diversity of peptides bound by HLA-C molecules.
