Stem and progenitor cells from the central nervous system:basic aspects and clinical relevance

Abstract

Aberrant neurogenesis has been correlated with different pathologiessuch as neurodegenerative diseases, epilepsy, Down syndrome anddepression. This review discusses the involvement of neural stemcells and neuroprogenitors in the development and maturation of thenervous system. In particular, the functional relevance of these cells to the central nervous system at both the physiological and pathological contexts is highlighted, along with new therapeutic strategies based on modulation of adult neurogenesis.

Keywords

• Stem cells
• Central nervous system/cytology
• Central nervous system/physiology
• Neurons/cytology
• Tissue therapy