Antimicrobial Stewardship & Healthcare Epidemiology (Jan 2024)
Multipronged strategy for protection and motivation of healthcare workers during the COVID-19 pandemic: a real-life study
- Madhumita Premkumar,
- Usha Dutta,
- Anchal Sandhu,
- Harman Kaur,
- Mini P Singh,
- Kapil Goyal,
- Rashmi Ranjan Guru,
- PVM Lakshmi,
- Madhu Gupta,
- Manisha Biswal,
- Arnab Ghosh,
- Anurag Sachan,
- Shikha Guleria,
- Swapanjeet Sahoo,
- Sandeep Grover,
- Tulika Gupta,
- Vipin Koushal,
- Mahesh Devnani,
- Shweta Talati,
- Ritin Mohindra,
- Vikas Suri,
- RK Ratho,
- Ashish Bhalla,
- Sanjay Jain,
- Pankaj Arora,
- Navin Pandey,
- Ashok Kumar,
- Arun K. Aggarwal,
- Arunaloke Chakrabarti,
- Goverdhan Dutt Puri,
- Jagat Ram,
- SS Pandav,
- Rakesh Sehgal,
- Pankaj Malhotra,
- Narayana Yaddanapuddi,
- Surjeet Singh,
- PGIMER COVID-19 Healthcare Worker Welfare Taskforce
Affiliations
- Madhumita Premkumar
- ORCiD
- Department of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Usha Dutta
- ORCiD
- Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Anchal Sandhu
- Department of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Harman Kaur
- Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Mini P Singh
- Department of Virology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Kapil Goyal
- Department of Virology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Rashmi Ranjan Guru
- Department of Hospital Administration, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- PVM Lakshmi
- ORCiD
- Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Madhu Gupta
- ORCiD
- Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Manisha Biswal
- Department of Microbiology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Arnab Ghosh
- ORCiD
- Department of Microbiology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Anurag Sachan
- Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Shikha Guleria
- Department of Hepatology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Swapanjeet Sahoo
- ORCiD
- Department of Psychiatry, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Sandeep Grover
- Department of Psychiatry, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Tulika Gupta
- Department of Anatomy Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Vipin Koushal
- ORCiD
- Department of Hospital Administration, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Mahesh Devnani
- ORCiD
- Department of Hospital Administration, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Shweta Talati
- ORCiD
- Department of Hospital Administration, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Ritin Mohindra
- Department of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Vikas Suri
- Department of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- RK Ratho
- Department of Virology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Ashish Bhalla
- ORCiD
- Department of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Sanjay Jain
- Department of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Pankaj Arora
- Department of Hospital Administration, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Navin Pandey
- Department of Hospital Administration, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Ashok Kumar
- Department of Hospital Administration, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Arun K. Aggarwal
- Department of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Arunaloke Chakrabarti
- Department of Microbiology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Goverdhan Dutt Puri
- Department of Anesthesia, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Jagat Ram
- Department of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- SS Pandav
- Department of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Rakesh Sehgal
- Department of Parasitology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Pankaj Malhotra
- Department of Hematology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Narayana Yaddanapuddi
- Department of Anesthesia, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- Surjeet Singh
- Department of Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
- PGIMER COVID-19 Healthcare Worker Welfare Taskforce
- DOI
- https://doi.org/10.1017/ash.2023.459
- Journal volume & issue
-
Vol. 4
Abstract
Abstract Objective: We aimed to assess risk of COVID-19 infection & seroprotection status in healthcare workers (HCWs) in both hospital and community settings following an intensive vaccination drive in India. Setting: Tertiary Care Hospital Methods: We surveyed COVID-19 exposure risk, personal protective equipment (PPE) compliance, vaccination status, mental health & COVID-19 infection rate across different HCW cadres. Elecsys® test for COVID-19 spike (Anti-SARS-CoV-2S; ACOVs) and nucleocapsid (Anti-SARS-CoV-2; ACOV) responses following vaccination and/or COVID-19 infection were measured in a stratified sample of 386 HCW. Results: We enrolled 945 HCWs (60.6% male, age 35.9 ± 9.8 years, 352 nurses, 211 doctors, 248 paramedics & 134 support staff). Hospital PPE compliance was 90.8%. Vaccination coverage was 891/945 (94.3%). ACOVs neutralizing antibody was reactive in 381/386 (98.7%). ACOVs titer (U/ml) was higher in the post-COVID-19 infection group (N =269; 242.1 ± 35.7 U/ml) than in the post-vaccine or never infected subgroup (N = 115, 204.1 ± 81.3 U/ml). RT PCR + COVID-19 infections were documented in 224/945 (23.7%) and 6 HCWs had disease of moderate severity, with no deaths. However, 232/386 (60.1%) of HCWs tested positive for nucleocapsid ACOV antibody, suggesting undocumented or subclinical COVID-19 infection. On multivariate logistic regression, only female gender [aOR 1.79, 95% CI 1.07–3.0, P = .025] and COVID-19 family contact [aOR 5.1, 95% CI 3.84–9.5, P < .001] were predictors of risk of developing COVID-19 infection, independent of association with patient-related exposure. Conclusion: Our HCWs were PPE compliant and vaccine motivated, with immunization coverage of 94.3% and seroprotection rate of 98.7%. There was no relationship between HCW COVID-19 infection to exposure characteristics in the hospital. Vaccination reduced disease severity and prevented death in HCW.
