Nature Communications (Mar 2021)
Cardiac macrophages prevent sudden death during heart stress
- Junichi Sugita,
- Katsuhito Fujiu,
- Yukiteru Nakayama,
- Takumi Matsubara,
- Jun Matsuda,
- Tsukasa Oshima,
- Yuxiang Liu,
- Yujin Maru,
- Eriko Hasumi,
- Toshiya Kojima,
- Hiroshi Seno,
- Keisuke Asano,
- Ayumu Ishijima,
- Naoki Tomii,
- Masatoshi Yamazaki,
- Fujimi Kudo,
- Ichiro Sakuma,
- Ryozo Nagai,
- Ichiro Manabe,
- Issei Komuro
Affiliations
- Junichi Sugita
- Department of Cardiovascular Medicine, the University of Tokyo
- Katsuhito Fujiu
- Department of Cardiovascular Medicine, the University of Tokyo
- Yukiteru Nakayama
- Department of Cardiovascular Medicine, the University of Tokyo
- Takumi Matsubara
- Department of Cardiovascular Medicine, the University of Tokyo
- Jun Matsuda
- Department of Cardiovascular Medicine, the University of Tokyo
- Tsukasa Oshima
- Department of Cardiovascular Medicine, the University of Tokyo
- Yuxiang Liu
- Department of Cardiovascular Medicine, the University of Tokyo
- Yujin Maru
- Department of Cardiovascular Medicine, the University of Tokyo
- Eriko Hasumi
- Department of Cardiovascular Medicine, the University of Tokyo
- Toshiya Kojima
- Department of Cardiovascular Medicine, the University of Tokyo
- Hiroshi Seno
- Medical Device Development and Regulation Research Center, Department of Bioengineering/Department of Precision Engineering, School of Engineering, The University of Tokyo
- Keisuke Asano
- Medical Device Development and Regulation Research Center, Department of Bioengineering/Department of Precision Engineering, School of Engineering, The University of Tokyo
- Ayumu Ishijima
- Medical Device Development and Regulation Research Center, Department of Bioengineering/Department of Precision Engineering, School of Engineering, The University of Tokyo
- Naoki Tomii
- Medical Device Development and Regulation Research Center, Department of Bioengineering/Department of Precision Engineering, School of Engineering, The University of Tokyo
- Masatoshi Yamazaki
- Medical Device Development and Regulation Research Center, Department of Bioengineering/Department of Precision Engineering, School of Engineering, The University of Tokyo
- Fujimi Kudo
- Department of Disease Biology and Molecular Medicine, Graduate School of Medicine, Chiba University
- Ichiro Sakuma
- Medical Device Development and Regulation Research Center, Department of Bioengineering/Department of Precision Engineering, School of Engineering, The University of Tokyo
- Ryozo Nagai
- Jichi Medical University
- Ichiro Manabe
- Department of Disease Biology and Molecular Medicine, Graduate School of Medicine, Chiba University
- Issei Komuro
- Department of Cardiovascular Medicine, the University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-021-22178-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Cardiac immune cells play various roles in the maintenance of homeostasis and diseases in the heart. Here the authors show that cardiac resident macrophages are a critical regulator of cardiac impulse conduction through amphiregulin production, contributing to the prevention of sudden death.
