Invasive Infection With emm3/ST15 Streptococcus pyogenes: The First Case Report From China and Complete Genome Analysis

Xinli Mu; Yanfei Wang; Lu Sun; Shanshan Zhao; Xi Jin; Junli Zhang; Yunsong Yu; Xueqing Wu

doi:10.3389/fmed.2022.861087

Frontiers in Medicine (May 2022)

Invasive Infection With emm3/ST15 Streptococcus pyogenes: The First Case Report From China and Complete Genome Analysis

Xinli Mu,
Yanfei Wang,
Lu Sun,
Shanshan Zhao,
Xi Jin,
Junli Zhang,
Yunsong Yu,
Xueqing Wu

Affiliations

Xinli Mu: Department of Infectious Diseases, Sir Run Run Shaw Hospital, Regional Medical Center for National Institute of Respiratory Diseases, Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China
Yanfei Wang: Department of Infectious Diseases, Sir Run Run Shaw Hospital, Regional Medical Center for National Institute of Respiratory Diseases, Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China
Lu Sun: Department of Infectious Diseases, Sir Run Run Shaw Hospital, Regional Medical Center for National Institute of Respiratory Diseases, Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China
Shanshan Zhao: Department of Clinical Laboratory, Shangyu People’s Hospital, Shaoxing, China
Xi Jin: Centre of Laboratory Medicine, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, China
Junli Zhang: Department of Infectious Diseases, Sir Run Run Shaw Hospital, Regional Medical Center for National Institute of Respiratory Diseases, Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China
Yunsong Yu: Department of Infectious Diseases, Sir Run Run Shaw Hospital, Regional Medical Center for National Institute of Respiratory Diseases, Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China
Xueqing Wu: Department of Infectious Diseases, Sir Run Run Shaw Hospital, Regional Medical Center for National Institute of Respiratory Diseases, Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China

DOI: https://doi.org/10.3389/fmed.2022.861087
Journal volume & issue: Vol. 9

Abstract

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Streptococcus pyogenes (GAS) may cause severe invasive disease with a high fatality rate, especially M3-type strains, which are less common in China. Here, we report the first emm3/ST15 invasive GAS infection case in China. The patient was diagnosed with severe skin and soft tissue infection (SSTI) and septicaemia caused by one GAS strain. Antibiotic susceptibility tests showed that the isolate was susceptible to all tested drugs. Antimicrobial therapy was then applied, and the patient fully recovered and was discharged from the hospital on Day 43. Whole-genome sequencing was carried out using the Illumina and Oxford Nanopore platforms and revealed this to be the first emm3/ST15-type GAS invasive infection in China. The closely related emm3/ST15-type GAS strains are MGAS315 from the United States and M3-b from Japan. Our finding is a warning that we should pay attention to invasive M3-type GAS infections in China and indicates the global spread of the highly virulent emm3/ST15 GAS strain.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

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