Immune checkpoint inhibitors⁃related nervous system adverse events

Abstract

Immune checkpoint inhibitors (ICIs) have been widely used in tumor treatment. Immune⁃related adverse events (irAEs) are common in skin, endocrine, gastrointestinal tract, liver and cardiovascular system symptoms. Nervous system adverse events are relatively rare, but the clinical presentations are various and difficult to identify. Neurologists should strengthen their understanding of neurologic immune⁃related adverse events (NirAEs), so as to enable the events to be identified in time, intervene as early as possible, and closely monitor the events, in order to improve the disease prognosis.

Keywords

• neoplasms
• immunosuppressive agents
• drug ⁃ related side effects and adverse reactions
• nervous system
• review