Identification of ferroptosis-associated genes and potential pharmacological targets in sepsis-induced myopathy
Dongfang Wang,
Ligang Xu,
Yukun Liu,
Chuntao Wang,
Zhikai Xu,
Fan Yang,
Zhanfei Li,
Xiangjun Bai,
Yiliu Liao,
Xiangping Liu,
Yuchang Wang
Affiliations
Dongfang Wang
Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, China; Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Ligang Xu
Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, China; Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Yukun Liu
Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Chuntao Wang
Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, China; Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Zhikai Xu
Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, China; Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Fan Yang
Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, China; Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Zhanfei Li
Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, China; Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Xiangjun Bai
Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, China; Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Yiliu Liao
Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, China; Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Xiangping Liu
Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Corresponding author.
Yuchang Wang
Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, China; Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Corresponding author. Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, China.
Background: The role of Ferroptosis in the course of sepsis-induced myopathy is yet unclear. The objective of our work is to identify key genes connected with Ferroptosis in sepsis-induced myopathy and investigate possible pharmaceutical targets related to this process. This research aims to provide new insights into the management of sepsis-induced myopathy. Methods: We got the GSE13205 dataset from the Gene Expression Omnibus (GEO) and extracted Ferroptosis-associated genes from the FerrDb database. After conducting a functional annotation analysis of these genes, we created a protein-protein interaction network using Cytoscape software to identify important genes. Subsequently, we employed CMap to investigate prospective pharmaceuticals that could target these crucial genes. Results: A total of 61 genes that are expressed differently (DEGs) have been found concerning Ferroptosis. These genes are involved in a wide range of biological functions, including reacting to signals from outside the cell and the availability of nutrients, programmed cell death, controlling apoptosis, and responding to peptides, chemical stressors, and hormones. The KEGG pathway study revealed that these pathways are involved in Ferroptosis, autophagy, P53 signaling, PI3K-Akt signaling, mTOR signaling, HIF-1 signaling, endocrine resistance, and different tumorigenic processes. In addition, we created a network that shows the simultaneous expression of important genes and determined the top 10 medications that have the potential to treat sepsis-induced myopathy. Conclusion: The bioinformatics research undertaken sheds insight into the probable role of Ferroptosis-associated genes in sepsis-induced myopathy. The identified critical genes show potential as therapeutic targets for treating sepsis-induced myopathy, offering opportunities for the development of tailored medicines.
