Molecular & Cellular Oncology (Nov 2017)
Breaking the end: Target the replication stress response at the ALT telomeres for cancer therapy
Abstract
We recently reported that depletion of FANCM in ALT cells induces replication stress mainly at their telomeres. Additionally, we found that co-depletion of FANCM and BLM, or FANCM and BRCA1 induces synthetic lethality in the ALT cells. Our new findings could have important implications for cancer prevention and treatment.
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