Results in Chemistry (Jan 2022)
Dithiocarbamates as potential PTP1B inhibitors for diabetes management
Abstract
A library of dithiocarbamate analogues were synthesized as inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B) as a potential treatment option for Type 2 Diabetes Mellitus (T2DM). Twenty analogues were synthesized and tested against PTP1B. Additionally, docking studies were conducted to analyse the binding interactions of the dithiocarbamate scaffold with the target enzyme. Subsequently, the binding affinities of the synthesized compounds were also determined. Although, no correlation between IC50 and ΔG was observed, a low of 0.8 μM and −6.8 Kcal/mol, respectively were obtained.
