Frontiers in Medicine (Nov 2022)
Blood monocyte counts as a prognostic biomarker and predictor in Chinese patients with idiopathic pulmonary fibrosis
- Xinran Zhang,
- Xinran Zhang,
- Xinran Zhang,
- Xinran Zhang,
- Yanhong Ren,
- Yanhong Ren,
- Yanhong Ren,
- Yanhong Ren,
- Bingbing Xie,
- Bingbing Xie,
- Bingbing Xie,
- Bingbing Xie,
- Qiao Ye,
- Chenjun Ban,
- Shu Zhang,
- Min Zhu,
- Yan Liu,
- Shiyao Wang,
- Shiyao Wang,
- Shiyao Wang,
- Shiyao Wang,
- Jing Geng,
- Jing Geng,
- Jing Geng,
- Jing Geng,
- Xuan He,
- Xuan He,
- Xuan He,
- Xuan He,
- Dingyuan Jiang,
- Dingyuan Jiang,
- Dingyuan Jiang,
- Dingyuan Jiang,
- Jiarui He,
- Jiarui He,
- Jiarui He,
- Jiarui He,
- Shi Shu,
- Shi Shu,
- Shi Shu,
- Shi Shu,
- Sa Luo,
- Sa Luo,
- Sa Luo,
- Sa Luo,
- Xin Wang,
- Xin Wang,
- Xin Wang,
- Xin Wang,
- Xin Wang,
- Dingyun Song,
- Dingyun Song,
- Dingyun Song,
- Dingyun Song,
- Mingming Fan,
- Mingming Fan,
- Mingming Fan,
- Mingming Fan,
- Mingming Fan,
- Haishuang Sun,
- Haishuang Sun,
- Haishuang Sun,
- Haishuang Sun,
- Haishuang Sun,
- Huaping Dai,
- Huaping Dai,
- Huaping Dai,
- Huaping Dai,
- Huaping Dai
Affiliations
- Xinran Zhang
- Department of Clinical Research and Data Management, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Xinran Zhang
- National Center for Respiratory Medicine, Beijing, China
- Xinran Zhang
- Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China
- Xinran Zhang
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Yanhong Ren
- National Center for Respiratory Medicine, Beijing, China
- Yanhong Ren
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Yanhong Ren
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Yanhong Ren
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Bingbing Xie
- National Center for Respiratory Medicine, Beijing, China
- Bingbing Xie
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Bingbing Xie
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Bingbing Xie
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Qiao Ye
- Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Chenjun Ban
- Department of Respiration, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
- Shu Zhang
- Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Min Zhu
- Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Yan Liu
- Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Shiyao Wang
- National Center for Respiratory Medicine, Beijing, China
- Shiyao Wang
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Shiyao Wang
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Shiyao Wang
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Jing Geng
- National Center for Respiratory Medicine, Beijing, China
- Jing Geng
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Jing Geng
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Jing Geng
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Xuan He
- National Center for Respiratory Medicine, Beijing, China
- Xuan He
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Xuan He
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Xuan He
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Dingyuan Jiang
- National Center for Respiratory Medicine, Beijing, China
- Dingyuan Jiang
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Dingyuan Jiang
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Dingyuan Jiang
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Jiarui He
- National Center for Respiratory Medicine, Beijing, China
- Jiarui He
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Jiarui He
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Jiarui He
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Shi Shu
- National Center for Respiratory Medicine, Beijing, China
- Shi Shu
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Shi Shu
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Shi Shu
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Sa Luo
- National Center for Respiratory Medicine, Beijing, China
- Sa Luo
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Sa Luo
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Sa Luo
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Xin Wang
- National Center for Respiratory Medicine, Beijing, China
- Xin Wang
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Xin Wang
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Xin Wang
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Xin Wang
- Beijing University of Chinese Medicine, Beijing, China
- Dingyun Song
- National Center for Respiratory Medicine, Beijing, China
- Dingyun Song
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Dingyun Song
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Dingyun Song
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Mingming Fan
- National Center for Respiratory Medicine, Beijing, China
- Mingming Fan
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Mingming Fan
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Mingming Fan
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Mingming Fan
- 0The Second Hospital of Jilin University, Changchun, China
- Haishuang Sun
- National Center for Respiratory Medicine, Beijing, China
- Haishuang Sun
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Haishuang Sun
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Haishuang Sun
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Haishuang Sun
- 1The First Hospital of Jilin University, Changchun, China
- Huaping Dai
- National Center for Respiratory Medicine, Beijing, China
- Huaping Dai
- National Clinical Research Center for Respiratory Diseases, Beijing, China
- Huaping Dai
- Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China
- Huaping Dai
- Institute of Respiratory Medicine, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
- Huaping Dai
- Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- DOI
- https://doi.org/10.3389/fmed.2022.955125
- Journal volume & issue
-
Vol. 9
Abstract
ObjectivesWe sought to evaluate the prognostic value of blood routine parameters and biochemical parameters, especially inflammation-related biomarkers, and establish an inflammation-related prognostic model in Chinese patients with idiopathic pulmonary fibrosis (IPF).Material/methodsPatients diagnosed as IPF at Beijing Chaoyang Hospital and aged 40 years and older were consecutively enrolled from June 2000 to March 2015, and finally, a total of 377 patients were enrolled in the derivation cohort. The follow-up ended in December 2016. We used Cox proportional hazard model to calculate the hazard ratio (HR) and establish the prognostic model. The discrimination and calibration of the prognostic model were evaluated in an independent validation cohort enrolled from China-Japan Friendship Hospital between January 2015 and December 2019.ResultsMultivariate analysis revealed that patients with elevated monocyte-to-red blood cell count ratio (MRR) and monocyte counts showed increased risk of mortality. The clinical-physiological-biomarker (CPB) index and CPB stage we established in this study were a significant predictor, and the C-index for CPB index and CPB stage in the validation cohort was 0.635 (95% CI: 0.558–0.712) and 0.619 (95% CI: 0.544–0.694), respectively. Patients in CPB stage III had the poorest survival.ConclusionWe developed and validated a new inflammation-related prognostic model (CPB index and CPB stage) which was integration of age, gender, FVC (%, predicted), DLCO (%, predicted), Charlson Comorbidity Index, and blood monocyte counts. This prediction model exhibited strong ability in predicting mortality in Chinese patients with IPF.
Keywords
