What is the optimal choice of antihypertensive therapy based on: the class-specific effects or special properties of a drug?

Abstract

The review article presents data on the significance of activation of different components of the renin-angiotensin-aldosterone system (RAAS) in metabolic disorder progression and organ damage processes. Based on the analysis of the pharmacological properties of drugs and clinical evidence, the authors discuss the problems of the choice of RAAS blockers. The mechanisms of drug action on metabolic processes, atherogenesis, and vascular damage are discussed.

Keywords

• renin-angiotensin-aldosterone system
• angiotensin-converting enzyme inhibitors
• hypertension
• perindopril