Nature Communications (Nov 2022)

A fourth dose of the inactivated SARS-CoV-2 vaccine redistributes humoral immunity to the N-terminal domain

  • Ji Wang,
  • Caiguangxi Deng,
  • Ming Liu,
  • Yihao Liu,
  • Liubing Li,
  • Zhangping Huang,
  • Liru Shang,
  • Juan Jiang,
  • Yongyong Li,
  • Ruohui Mo,
  • Hui Zhang,
  • Min Liu,
  • Sui Peng,
  • Haipeng Xiao

DOI
https://doi.org/10.1038/s41467-022-34633-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 11

Abstract

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Despite the availability of booster doses against SARS-CoV-2, variants of concern are capable of escaping immune responses established by vaccination or natural infection. In this work, the authors detail the immune responses elicited in a cohort of healthcare workers, receiving a fourth dose of inactivated vaccine.