Pengaruh ekstrak kulit umbi bawang putih (Allium sativum L.) terhadap kadar kolesterol darah total tikus jantan galur wistar diabetes mellitus

Abstract

Diabetes Mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia. DM patient with elevated levels of blood glucose increase the risk lipid metabolism disorder. Skin of garlic containcompounds of alkaloid, quinone, flavonoid, saponin, and polyphenol which can lower blood glucose level. This study objective was to explore the effect of garlic (Allium sativum L.) skin extract towards bloodtotal cholesterol levels in diabetic male Wistar rats. Skin of garlic was macerated by ethanol 70% with ratio 1:10. Twenty-five male Wistar rats was divided into 5 groups, 1st group was baseline; 2nd group was as aloxan control which was administered with single dose of alloxan 160 mg/kg BW by intra peritoneal; 3rd, 4th and 5th groups were induced by a single dose of alloxan 160 mg/kg BW by intra peritoneal and administered by garlic skin extract dose 1000 mg/kg BW, 2000 mg/kg BW, and 4000 mg/kg BW by oral for 14 days. Data was analyzed statistically with Kruskal-Wallis and Mann-Whitney. The results showed that there was a significant difference between the control negative group and the baseline, 3rd, 4th, and 5th groups. The garlic skin extract dose 1000 mg/kg BW, 2000 mg/kg BW, and 4000 mg/kg BW could lower the blood total cholesterol levels in diabetic male Wistar rats.

Keywords

• cholesterol
• diabetes mellitus
• the garlic skin extract