561 Targeting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

• Nir Hacohen,
• Soldano Ferrone,
• Keith Flaherty,
• Tatyana Sharova,
• Genevieve M Boland,
• Robert T Manguso,
• Payal Tiwari,
• Debattama R Sen,
• Arnav Mehta,
• William Michaud,
• Or-Yam Revach,
• Angelina Cicerchia,
• Moshe Sade-Feldman,
• Seth Anderson,
• Boryana Petrova,
• Ofir Shorer,
• Lloyd Bod,
• Giulia Cattaneo,
• Hongyan Xie,
• Martin Rasmussen,
• Jacy Fang,
• Keren Yizhak,
• Naama Kanarek,
• Russell Jenkins

Affiliations

Nir Hacohen

1Broad Institute of MIT and Harvard, Cambridge, MA, USA

Soldano Ferrone

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

Keith Flaherty

2Massachusetts General Hospital, Boston, MA, USA

Tatyana Sharova

Department of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

Genevieve M Boland

Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

Robert T Manguso

3Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA

Payal Tiwari

6Broad Institute of MIT and Harvard, Cambridge, MA, USA

Debattama R Sen

3Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA

Arnav Mehta

2Massachusetts General Hospital, Boston, MA, USA

William Michaud

2Massachusetts General Hospital, Boston, MA, USA

Or-Yam Revach

1Massachusetts General Hospital, Cambridge, MA, USA

Angelina Cicerchia

2Mass General Hospital Cancer Center, Massachusetts General Hospital Boston, MA, USA

Moshe Sade-Feldman

2Mass General Hospital Cancer Center, Massachusetts General Hospital Boston, MA, USA

Seth Anderson

3Broad Institute of MIT and Harvard, Cambridge, MA, USA

Boryana Petrova

4Department of Pathology, Boston Children’s Hospital, Boston MA, Boston, MA, USA

Ofir Shorer

5The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel, Israel

Lloyd Bod

2Mass General Hospital Cancer Center, Massachusetts General Hospital Boston, MA, USA

Giulia Cattaneo

7Massachusetts General Hospital, Boston, MA, USA

Hongyan Xie

7Massachusetts General Hospital, Boston, MA, USA

Martin Rasmussen

2Mass General Hospital Cancer Center, Massachusetts General Hospital Boston, MA, USA

Jacy Fang

2Mass General Hospital Cancer Center, Massachusetts General Hospital Boston, MA, USA

Keren Yizhak

10Technion Israel Institute of Technology, Haifa, Israel

Naama Kanarek

4Department of Pathology, Boston Children’s Hospital, Boston MA, Boston, MA, USA

Russell Jenkins

2Mass General Hospital Cancer Center, Massachusetts General Hospital Boston, MA, USA