Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics

Abstract

In this work we present for the first time the synthesis of novel 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) derivatives that can be used as tools in the emerging field of epigenetics for deciphering chemical biology of TET-mediated processes.

Keywords

• 3,6-dihydrodeoxycytidine derivatives
• DNA demethylation
• epigenetics
• 5-hydroxymethylcytosine (5hmC) derivatives
• TET-enzymes