Quantitative and Qualitative Scintigraphic Measurement of Renal Function in Persian Cat Using 99mTechnetium Ethylenedicysteine and 99mTechnetium Diethylenetriaminepentaacetic

Abstract

Objective- To consider the use of renal scintigraphic evaluation of kidney function in Persian cat and make a comparison between 99mTechnetium ethylenedicysteine and 99mTechnetium diethylenetriaminepentaacetic in renal scintigraphy. Design- Descriptive study Animals- 6 male healthy adult Persian cats - no clinical sign of renal disorders and prior to presentation. Procedure- The scintigraphy of right and left kidney using Gamma camera (Piker Model) and 99mTc-EC and 99mTc-DTPA as radiopharmaceuticals. Peak activity percentage (% PA), peak time (Tmax), half emptying-time (T1/2), total and individual GFR and flow and function time activity curves (TACs) are the determined parameters in this evaluation. Results- % PA, Tmax and T1/2 in left and right kidney for 99mTc-EC and 99mTc-DTPA respectively, were 49/86 %, 50/1 %, 11/3 min, 11/5 min, 4/4 min, 4/6 min and 51/27 %, 49/05 %, 7/7 min, 8/3 min, 3 min, 3/43 min. Moreover the quantities of total and individual GFR for left and right kidney measured by 99mTc-DTPA measured by modified Gates technique respectively, were 125/69 ml/min, 64/42ml/min (51/26 %), 61/24ml/min (48/73 %) and were in normal range defined by Gates technique. Conclusion and Clinical Relevance- normal indices obtained for listed parameters and total and individual GFR quantities can play a major role in order to diagnose kidney disorder or function deterioration and can be a background and specialized knowledge conducive to future studies. Also comparison of two radiopharmaceuticals 99mTc-EC and 99mTc-DTPA showed that 99mTc-DTPA scintigraphy has the superiority to assess the quantities of total and individual GFR so we can use 99mTc-DTPA to evaluate Glomerular filtration rate in both kidneys.

Keywords

• scintigraphy
• Kidney
• Cat