Prediction of development and clinical course of the minimal brain dysfunction

Abstract

The study included. 173 children with minimal brain dysfunction. (MBD) at the age of 2-8 years and 90 healthy children comparable by age and sex. As the result of dynamic examination we revealed two types of clinical course: favorable, showed as a regredient variant, and. unfavorable type, showed as a regredient variant with light residual organic cerebral insufficiency and. progredient variant. Favorable type of MBD course was observed in 70.3 % of children of pre-preschool age and. only in 22,2 % of children of the early school age. Unfavorable type was is 2,5 times more often in the group of children of early school age. Prognostically important risk factors were determined, by discriminant analysis, the degree of their mutual influence both on the development and. clinical course of MBD were defined. A system for individual prediction of development and. clinical course of MBD that allows revealing the children with risk of appearance of the disease with 95,4 % accuracy was developed. Determination of type of clinical course of MBD with 98,2 % accuracy gives the chance to carry out individual treatment and. preventive measures, including the correction of the most significant "controlled" risk factors in proper time.

Keywords

• minimal brain dysfunction
• risk factors
• discriminant analysis
• prediction