Nature Communications (May 2016)
Tumour resistance in induced pluripotent stem cells derived from naked mole-rats
- Shingo Miyawaki,
- Yoshimi Kawamura,
- Yuki Oiwa,
- Atsushi Shimizu,
- Tsuyoshi Hachiya,
- Hidemasa Bono,
- Ikuko Koya,
- Yohei Okada,
- Tokuhiro Kimura,
- Yoshihiro Tsuchiya,
- Sadafumi Suzuki,
- Nobuyuki Onishi,
- Naoko Kuzumaki,
- Yumi Matsuzaki,
- Minoru Narita,
- Eiji Ikeda,
- Kazuo Okanoya,
- Ken-ichiro Seino,
- Hideyuki Saya,
- Hideyuki Okano,
- Kyoko Miura
Affiliations
- Shingo Miyawaki
- Biomedical Animal Research Laboratory, Institute for Genetic Medicine, Hokkaido University
- Yoshimi Kawamura
- Biomedical Animal Research Laboratory, Institute for Genetic Medicine, Hokkaido University
- Yuki Oiwa
- Biomedical Animal Research Laboratory, Institute for Genetic Medicine, Hokkaido University
- Atsushi Shimizu
- Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University
- Tsuyoshi Hachiya
- Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University
- Hidemasa Bono
- Database Center for Life Science, Research Organization of Information and Systems
- Ikuko Koya
- Department of Physiology, Keio University School of Medicine
- Yohei Okada
- Department of Physiology, Keio University School of Medicine
- Tokuhiro Kimura
- Department of Pathology, Yamaguchi University Graduate School of Medicine
- Yoshihiro Tsuchiya
- Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences
- Sadafumi Suzuki
- Department of Physiology, Keio University School of Medicine
- Nobuyuki Onishi
- Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
- Naoko Kuzumaki
- Department of Physiology, Keio University School of Medicine
- Yumi Matsuzaki
- Department of Life Science, Shimane University Faculty of Medicine
- Minoru Narita
- Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences
- Eiji Ikeda
- Department of Pathology, Yamaguchi University Graduate School of Medicine
- Kazuo Okanoya
- Graduate School of Arts and Science, The University of Tokyo
- Ken-ichiro Seino
- Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University
- Hideyuki Saya
- Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
- Hideyuki Okano
- Department of Physiology, Keio University School of Medicine
- Kyoko Miura
- Biomedical Animal Research Laboratory, Institute for Genetic Medicine, Hokkaido University
- DOI
- https://doi.org/10.1038/ncomms11471
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 9
Abstract
The naked mole-rat exhibits an exceptional resistance to cancer. Here, the authors show that induced pluripotent stem cells derived from the naked mole-rat lack teratoma-forming tumorigenicity due to a naked mole-rat-specific ARF-dependent tumour-suppression mechanism.
