La infección gástrica por helicobacter pylori modifica la secreción de ácido

Abstract

The most important factor associated with the etiology of gastritis and peptic ulcer is Helicobacter pylori. It also has been implicated in the described alterations of the gastrinsomatostatin-acid relationships. In this work we investigated prospectively the changes in gastric acid secretion observed after a triple therapy for H. pylori eradication with bismuth, tetracycline and furazolidone. Patients with non ulcer dispepsia and a H.pylori associated chronic gastritis were investigated. An upper GI endoscopy and a basal and pentagastrin stimulated acid secretion tests were performed. A 2nd. Secretory test was done at 5 (Group l) and 14 days (Group II) after starting antibiotic therapy. Results. 27 patients were investigated. Acid concentrations values in both groups increased significatively in basal and stimulated conditions compared to the initial results, at 5 and 14 days of starting drugs. Stimulated acid output also had an increase. Conclusion. A therapy for H.pylori eradication induces an early increase of gastric acid parameters. Factors involved in this change are probably inflammatory mediators such us 1-Interleukin, as at 5th day a complete bacterial eradication is not probably. Presence of chronic lower acid secretion rates could be implicated in the etiology of gastric cancer as it can induce bacterial overgrowth and deserves further epidemiological investigation.

Keywords

• infecciones por helicobacter
• diagnóstico
• microbiologia
• helicobacter pylori
• histopatología
• mucosa gástrica