Comparative Investigation of Rheological Characteristics of the Original Drug Triderm and Its Generics in the Form of Cream

Abstract

Rheological properties of mild pharmaceutical formulations (creams) with glucocorticosteroids, such as Triderm (Belgium), Akriderm GK (Russia) and Kanizon plus (India) were studied. The study revealed differences in the structural-strength properties of the medicines (viscosity, critical shear stress). The necessity of rheological investigations during development of generic medicines was shown.

Keywords

• creams
• rheological studies
• structural-strength properties
• viscosity
• shear stress