Communications Biology (Feb 2021)

Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells

  • Diego Crespo,
  • Luiz H. C. Assis,
  • Yu Ting Zhang,
  • Diego Safian,
  • Tomasz Furmanek,
  • Kai Ove Skaftnesmo,
  • Birgitta Norberg,
  • Wei Ge,
  • Yung-Ching Choi,
  • Marjo J. den Broeder,
  • Juliette Legler,
  • Jan Bogerd,
  • Rüdiger W. Schulz

DOI
https://doi.org/10.1038/s42003-021-01708-y
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 13

Abstract

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Insulin-like 3 (Insl3) belongs to a class of peptide hormones that are expressed in the Leydig cells and, in zebrafish, under the control of folliclestimulating hormone (Fsh) in the pituitary. Using insl3 knockout zebrafish, the authors found that Insl3 regulates spermatogonia differentiation and apoptosis via the Pparg and retinoic acid pathways.