Association of D-dimer and acute kidney injury associated with rhabdomyolysis in patients with exertional heatstroke: an over 10-year intensive care survey
Conglin Wang,
Baojun Yu,
Ronglin Chen,
Lei Su,
Ming Wu,
Zhifeng Liu
Affiliations
Conglin Wang
Department of Critical Care Medicine, General Hospital of Southern Theatre Command of Peoples Liberation Army
Baojun Yu
The First School of Clinical Medicine, Southern Medical University
Ronglin Chen
Department of Critical Care Medicine, General Hospital of Southern Theatre Command of Peoples Liberation Army
Lei Su
Department of Critical Care Medicine, General Hospital of Southern Theatre Command of Peoples Liberation Army
Ming Wu
Department of Critical Care Medicine and Hospital Infection Prevention and Control, The Second People’s Hospital of Shenzhen & First Affiliated Hospital of Shenzhen University, Health Science Center
Zhifeng Liu
Department of Critical Care Medicine, General Hospital of Southern Theatre Command of Peoples Liberation Army
Patients with rhabdomyolysis (RM) following exertional heatstroke (EHS) are often accompanied by dysfunction of coagulation and acute kidney injury (AKI). The purpose of this study was to investigate the relationship between D-dimer and AKI in patients with RM following EHS. A retrospective study was performed on patients with EHS admitted to the intensive care unit over 10-year. Data including baseline clinical information at admission, vital organ dysfunction, and 90-day mortality were collected. A total of 84 patients were finally included, of whom 41 (48.8%) had AKI. AKI patients had more severe organ injury and higher 90-day mortality (34.1 vs.0.0%, p 0.4 mg/L, in the non-RM group (OR 6.4, 95% CI 1.7–23.9, p = 0.005) when D-dimer 1.3 mg/L. AKI is a life-threatening complication of RM following EHS. D-dimer is associated with AKI in critically ill patients with EHS. The relationship between D-dimer and AKI depends on whether RM is present or not.
