An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO<sub>2</sub>
Renle Cui,
Caihong Liu,
Ping Zhang,
Kun Qin,
Yanqing Ge
Affiliations
Renle Cui
Department of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, China
Caihong Liu
Department of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, China
Ping Zhang
Department of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, China
Kun Qin
Department of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, China
Yanqing Ge
Department of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, China
A mitochondria-targeted NIR probe based on the FRET mechanism was developed. It shows ultra-large Stokes shifts (460 nm) and emission shifts (285 nm). Furthermore, we also realized the imaging of SO2 in living SKOV-3 cells, zebrafish and living mice which may be useful for understanding the biological roles of SO2 in mitochondria and in vivo.
