Polysaccharides Extracted from <i>Dendrobium officinale</i> Grown in Different Environments Elicit Varying Health Benefits in <i>Caenorhabditis elegans</i>

Abstract

Dendrobium officinale is one of the most widely used medicinal herbs, especially in Asia. In recent times, the polysaccharide content of D. officinale has garnered attention due to the numerous reports of its medicinal properties, such as anticancer, antioxidant, anti-diabetic, hepatoprotective, neuroprotective, and anti-aging activities. However, few reports of its anti-aging potential are available. Due to high demand, the wild D. officinale is scarce; hence, alternative cultivation methods are being employed. In this study, we used the Caenorhabditis elegans model to investigate the anti-aging potential of polysaccharides extracted from D. officinale (DOP) grown in three different environments; tree (TR), greenhouse (GH), and rock (RK). Our findings showed that at 1000 µg/mL, GH-DOP optimally extended the mean lifespan by 14% and the maximum lifespan by 25% (p 2O2-induced stress (p > 0.05, p p p p D. officinale for maximum medicinal applications.

Keywords

• aging
• <i>Caenorhabditis elegans</i>
• <i>Dendrobium officinale</i>
• lifespan
• polysaccharides