Nature Communications (Dec 2022)
The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing
- Mariana P. Cervantes-Silva,
- Richard G. Carroll,
- Mieszko M. Wilk,
- Diana Moreira,
- Cloe A. Payet,
- James R. O’Siorain,
- Shannon L. Cox,
- Lauren E. Fagan,
- Paula A. Klavina,
- Yan He,
- Tabea Drewinski,
- Alan McGinley,
- Sharleen M. Buel,
- George A. Timmons,
- James O. Early,
- Roger J. S. Preston,
- Jennifer M. Hurley,
- David K. Finlay,
- Ingmar Schoen,
- F. Javier Sánchez-García,
- Kingston H. G. Mills,
- Annie M. Curtis
Affiliations
- Mariana P. Cervantes-Silva
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- Richard G. Carroll
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- Mieszko M. Wilk
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
- Diana Moreira
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
- Cloe A. Payet
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- James R. O’Siorain
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- Shannon L. Cox
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- Lauren E. Fagan
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- Paula A. Klavina
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- Yan He
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- Tabea Drewinski
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- Alan McGinley
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- Sharleen M. Buel
- Department of Biological Sciences & Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute
- George A. Timmons
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- James O. Early
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- Roger J. S. Preston
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- Jennifer M. Hurley
- Department of Biological Sciences & Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute
- David K. Finlay
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
- Ingmar Schoen
- Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- F. Javier Sánchez-García
- Immunoregulation Laboratory, Department of Immunology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional
- Kingston H. G. Mills
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
- Annie M. Curtis
- Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland RCSI
- DOI
- https://doi.org/10.1038/s41467-022-34897-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Circadian rhythms are known to impact a range of biological processes including in the immune system. Here the authors show how circadian rhythms modulate the T cell response to vaccination via regulation of dendritic cell metabolism.
