Communications Biology (Nov 2022)

The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation

  • Balpreet Bhogal,
  • Barbara A. Weir,
  • Ramona Crescenzo,
  • Ann Marien,
  • Min Chul Kwon,
  • Ulrike Philippar,
  • Glenn S. Cowley

DOI
https://doi.org/10.1038/s42003-022-04139-5
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 13

Abstract

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The methyltransferase domain of DNA methyltransferase protein 1 is an essential functional domain in acute myeloid leukemia, which is independent of DNMT3A mutation.