Relationship of serum zinc with high-impact clinical-metabolic profiles in Mexican population

Abstract

Background: Zinc is related to the regulation of the different metabolic processes that are associated with diseases. Objective: To determine the relationship of serum Zn (S-Zn) with the high-impact clinical–metabolic profiles. Methods: In 191 subjects, we set the high-impact clinical–metabolic profiles and principal diagnostic parameters by principal component analysis of diagnostic parameters. S-Zn levels were measured by atomic absorption spectrophotometry. Results: Three high-impact clinical–metabolic profiles were determined with a cumulative variance of 52.4%. The ZnS levels were related to two profiles, “Impaired insulin action and obesity” (Profile 1), and “Impaired glycemia and middle age” (Profile 2). Profile (1) Significantly lower ZnS levels in subjects with insulin resistance (IR) when compared to subjects without IR (p = 0.014), significantly lower ZnS levels in subjects with abdominal obesity compared to subjects without abdominal obesity (p = 0.006) and, a negative and significant correlation of ZnS levels with HOMA2-IR (p = 0.037). Profile (2) Significantly lower ZnS levels in subjects with diabetes compared to subjects without diabetes (p < 0.001) and, a negative and significant correlation of ZnS levels with fasting glucose (p = 0.032) and HbA1c (p < 0.028). Conclusions: The decrease in zinc levels could be relationship to the presence of high-impact clinical metabolic profiles regardless of age, total fat, and gender.

Keywords

• Zinc. Clinical–metabolic profile. HOMA-IR. HbA1c.