Coordinated integrin activation by actin-dependent force during T-cell migration

Pontus Nordenfelt; Hunter L. Elliott; Timothy A. Springer

doi:10.1038/ncomms13119

Nature Communications (Oct 2016)

Coordinated integrin activation by actin-dependent force during T-cell migration

Pontus Nordenfelt,
Hunter L. Elliott,
Timothy A. Springer

Affiliations

Pontus Nordenfelt: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Program in Cellular and Molecular Medicine, Children’s Hospital Boston
Hunter L. Elliott: Image and Data Analysis Core, Harvard Medical School
Timothy A. Springer: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Program in Cellular and Molecular Medicine, Children’s Hospital Boston

DOI: https://doi.org/10.1038/ncomms13119
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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The role of force in activating integrin cell adhesion receptors is not known. Here the authors develop fluorescent tension sensors for αL and β2 integrins and show that in migrating T cells force is transduced across the β2 integrin, and that this correlates with an active conformational state.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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