Frontiers in Immunology (May 2024)
Apolipoprotein D facilitates rabies virus propagation by interacting with G protein and upregulating cholesterol
- Hongyan Zhang,
- Hongyan Zhang,
- Xingxue Liang,
- Xingxue Liang,
- Duoduo Li,
- Duoduo Li,
- Chuanliang Zhang,
- Chuanliang Zhang,
- Wenfeng Wang,
- Wenfeng Wang,
- Rongze Tang,
- Rongze Tang,
- Hongyun Zhang,
- Hongyun Zhang,
- Abraha Bahlbi Kiflu,
- Abraha Bahlbi Kiflu,
- Cheng Liu,
- Cheng Liu,
- Cheng Liu,
- Cheng Liu,
- Jingjing Liang,
- Jingjing Liang,
- Jingjing Liang,
- Jingjing Liang,
- Xiaoning Li,
- Xiaoning Li,
- Xiaoning Li,
- Xiaoning Li,
- Ting Rong Luo,
- Ting Rong Luo,
- Ting Rong Luo,
- Ting Rong Luo
Affiliations
- Hongyan Zhang
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China
- Hongyan Zhang
- College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
- Xingxue Liang
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China
- Xingxue Liang
- College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
- Duoduo Li
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China
- Duoduo Li
- College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
- Chuanliang Zhang
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China
- Chuanliang Zhang
- College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
- Wenfeng Wang
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China
- Wenfeng Wang
- College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
- Rongze Tang
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China
- Rongze Tang
- College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
- Hongyun Zhang
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China
- Hongyun Zhang
- College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
- Abraha Bahlbi Kiflu
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China
- Abraha Bahlbi Kiflu
- College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
- Cheng Liu
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China
- Cheng Liu
- College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
- Cheng Liu
- Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, China
- Cheng Liu
- Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Guangxi University, Nanning, China
- Jingjing Liang
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China
- Jingjing Liang
- College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
- Jingjing Liang
- Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, China
- Jingjing Liang
- Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Guangxi University, Nanning, China
- Xiaoning Li
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China
- Xiaoning Li
- College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
- Xiaoning Li
- Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, China
- Xiaoning Li
- Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Guangxi University, Nanning, China
- Ting Rong Luo
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, China
- Ting Rong Luo
- College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
- Ting Rong Luo
- Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, China
- Ting Rong Luo
- Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Guangxi University, Nanning, China
- DOI
- https://doi.org/10.3389/fimmu.2024.1392804
- Journal volume & issue
-
Vol. 15
Abstract
Rabies virus (RABV) causes a fatal neurological disease, consisting of unsegmented negative-strand RNA, which encodes five structural proteins (3′-N-P-M-G-L-5′). Apolipoprotein D (ApoD), a lipocalin, is upregulated in the nervous system after injury or pathological changes. Few studies have focused on the role of ApoD during virus infection so far. This study demonstrated that ApoD is upregulated in the mouse brain (in vivo) and C8-D1A cells (in vitro) after RABV infection. By upregulating ApoD expression in C8-D1A cells, we found that ApoD facilitated RABV replication. Additionally, Co-immunoprecipitation demonstrated that ApoD interacted with RABV glycoprotein (G protein). The interaction could promote RABV replication by upregulating the cholesterol level. These findings revealed a novel role of ApoD in promoting RABV replication and provided a potential therapeutic target for rabies.
Keywords
