Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections

Abstract

To determine neutralizing activity against the severe acute respiratory syndrome coronavirus 2 ancestral strain and 4 variants of concern, we tested serum from 30 persons with breakthrough infection after 2-dose vaccination. Cross-variant neutralizing activity was comparable to that after 3-dose vaccination. Shorter intervals between vaccination and breakthrough infection correlated with lower neutralizing titers.

Keywords

• COVID-19
• 2019 novel coronavirus disease
• coronavirus disease
• severe acute respiratory syndrome coronavirus 2
• SARS-CoV-2
• viruses