Nature Communications (Nov 2022)
Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis
- Yael Aylon,
- Noa Furth,
- Giuseppe Mallel,
- Gilgi Friedlander,
- Nishanth Belugali Nataraj,
- Meng Dong,
- Ori Hassin,
- Rawan Zoabi,
- Benjamin Cohen,
- Vanessa Drendel,
- Tomer Meir Salame,
- Saptaparna Mukherjee,
- Nofar Harpaz,
- Randy Johnson,
- Walter E. Aulitzky,
- Yosef Yarden,
- Efrat Shema,
- Moshe Oren
Affiliations
- Yael Aylon
- Department of Molecular Cell Biology, The Weizmann Institute of Science
- Noa Furth
- Department of Immunology and Regenerative Biology, The Weizmann Institute of Science
- Giuseppe Mallel
- Department of Molecular Cell Biology, The Weizmann Institute of Science
- Gilgi Friedlander
- Department of Life Sciences Core Facilities, The Nancy & Stephen Grand Israel National Center for Personalized Medicine (G-INCPM), The Weizmann Institute of Science
- Nishanth Belugali Nataraj
- Department of Immunology and Regenerative Biology, The Weizmann Institute of Science
- Meng Dong
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology and University of Tuebingen
- Ori Hassin
- Department of Molecular Cell Biology, The Weizmann Institute of Science
- Rawan Zoabi
- Department of Molecular Cell Biology, The Weizmann Institute of Science
- Benjamin Cohen
- Department of Immunology, The Weizmann Institute of Science
- Vanessa Drendel
- Department of Pathology, Robert Bosch Hospital
- Tomer Meir Salame
- Flow Cytometry Unit, Department of Life Sciences Core Facilities, The Weizmann Institute of Science
- Saptaparna Mukherjee
- Department of Molecular Cell Biology, The Weizmann Institute of Science
- Nofar Harpaz
- Department of Immunology and Regenerative Biology, The Weizmann Institute of Science
- Randy Johnson
- Department of Cancer Biology, University of Texas MD Anderson Cancer Center
- Walter E. Aulitzky
- Department of Hematology, Oncology and Palliative Medicine, Robert Bosch Hospital
- Yosef Yarden
- Department of Immunology and Regenerative Biology, The Weizmann Institute of Science
- Efrat Shema
- Department of Immunology and Regenerative Biology, The Weizmann Institute of Science
- Moshe Oren
- Department of Molecular Cell Biology, The Weizmann Institute of Science
- DOI
- https://doi.org/10.1038/s41467-022-34863-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
LATS1 is reported to regulate the transition of luminal-basal-like cell plasticity in breast cancer. Here the authors report that LATS1 limits the progression of luminal breast cancer by associating with NCOR1 nuclear corepressor to repress ERα-downregulated genes in luminal cells.
