Effects of music on stress induced hormones and oxidative stress levels

Abstract

Purpose: Perinatal stress, anxiety, and depression have been thought having influences on the developmental period of organisms. In this study, we aimed to investigate the effects of different types of music exposure during perinatal period on depression-like behavior, serum levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT) and parathyroid hormone (PTH) as well as serum oxidative stress index in rats. Materials and Methods: Pregnant Wistar albino rats were randomly divided into four cages; the control group (no music exposure), the classical music group (Canon in D Major/ Johann Pachelbel, 60 dB), the traditional Sufi music group (Whirling Derwish/ Omar Faruk Tekbilek, 30 dB), and the rock music group (In Your Face/ Children of Bodom, 120 dB). Dams and pups in each music groups listened to their own music 1 hour/day from gestational day 10 to postnatal day 21. Results: According to the results of tail suspension test, the longer duration of immobility which shows the level of depression was increased in the classical music group compared to the control group. At hormonal level, significant alterations were obtained only in serum ACTH levels. It was increased in the classical music group, while decreased in the sufi music group compared to the control group. In addition, a marked increase in oxidative stress index was found in the rock music group compared to the control group. Conclusion: The sound intensity of music which is listened during the pregnancy has vital importance in the stress and depression level of offspring.

Keywords

• hypothalamic-pituitary-adrenal (hpa) axis
• perinatal music
• depression-like behavior
• parathyroid hormone (pth)
• oxidative stress
• hipotalamik-hipofiz-adrenal (hpa) ekseni
• perinatal müzik
• depresyon benzeri davranış
• paratiroid hormon
• oksidatif stres