Nature Communications (Jan 2020)
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
- Marta Pradas-Juni,
- Nils R. Hansmeier,
- Jenny C. Link,
- Elena Schmidt,
- Bjørk Ditlev Larsen,
- Paul Klemm,
- Nicola Meola,
- Hande Topel,
- Rute Loureiro,
- Ines Dhaouadi,
- Christoph A. Kiefer,
- Robin Schwarzer,
- Sajjad Khani,
- Matteo Oliverio,
- Motoharu Awazawa,
- Peter Frommolt,
- Joerg Heeren,
- Ludger Scheja,
- Markus Heine,
- Christoph Dieterich,
- Hildegard Büning,
- Ling Yang,
- Haiming Cao,
- Dario F. De Jesus,
- Rohit N. Kulkarni,
- Branko Zevnik,
- Simon E. Tröder,
- Uwe Knippschild,
- Peter A. Edwards,
- Richard G. Lee,
- Masayuki Yamamoto,
- Igor Ulitsky,
- Eduardo Fernandez-Rebollo,
- Thomas Q. de Aguiar Vallim,
- Jan-Wilhelm Kornfeld
Affiliations
- Marta Pradas-Juni
- Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark
- Nils R. Hansmeier
- Max Planck Institute for Metabolism Research
- Jenny C. Link
- Department of Biological Chemistry, University of California, Los Angeles (UCLA)
- Elena Schmidt
- Max Planck Institute for Metabolism Research
- Bjørk Ditlev Larsen
- Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark
- Paul Klemm
- Max Planck Institute for Metabolism Research
- Nicola Meola
- Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark
- Hande Topel
- Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark
- Rute Loureiro
- Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark
- Ines Dhaouadi
- Max Planck Institute for Metabolism Research
- Christoph A. Kiefer
- Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark
- Robin Schwarzer
- Cologne Cluster of Excellence—Cellular Stress Responses in Ageing-associated Diseases (CECAD), Medical Faculty, University of Cologne
- Sajjad Khani
- Max Planck Institute for Metabolism Research
- Matteo Oliverio
- Max Planck Institute for Metabolism Research
- Motoharu Awazawa
- Max Planck Institute for Metabolism Research
- Peter Frommolt
- Cologne Cluster of Excellence—Cellular Stress Responses in Ageing-associated Diseases (CECAD), Medical Faculty, University of Cologne
- Joerg Heeren
- Department of Biochemistry and Molecular Cell Biology
- Ludger Scheja
- Department of Biochemistry and Molecular Cell Biology
- Markus Heine
- Department of Biochemistry and Molecular Cell Biology
- Christoph Dieterich
- Section of Bioinformatics and Systems Cardiology, Klaus Tschira Institute for Integrative Computational Cardiology, University Hospital Heidelberg
- Hildegard Büning
- Institute of Experimental Hematology, Hanover Medical School
- Ling Yang
- Cardiovascular Branch, National Heart Lung and Blood Institute
- Haiming Cao
- Cardiovascular Branch, National Heart Lung and Blood Institute
- Dario F. De Jesus
- Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Stem Cell Institute, Harvard Medical School
- Rohit N. Kulkarni
- Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Stem Cell Institute, Harvard Medical School
- Branko Zevnik
- CECAD in vivo Research Facility, Medical Faculty, University of Cologne
- Simon E. Tröder
- CECAD in vivo Research Facility, Medical Faculty, University of Cologne
- Uwe Knippschild
- Department of General and Visceral Surgery, University Hospital Ulm
- Peter A. Edwards
- Department of Biological Chemistry, University of California, Los Angeles (UCLA)
- Richard G. Lee
- IONIS Pharmaceuticals
- Masayuki Yamamoto
- Department of Medical Biochemistry, Tohoku Medical Megabank Organization
- Igor Ulitsky
- Department of Biological Regulation, Weizmann Institute of Science
- Eduardo Fernandez-Rebollo
- Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark
- Thomas Q. de Aguiar Vallim
- Department of Biological Chemistry, University of California, Los Angeles (UCLA)
- Jan-Wilhelm Kornfeld
- Functional Genomics and Metabolism Unit, Department for Biochemistry and Molecular Biology, University of Southern Denmark
- DOI
- https://doi.org/10.1038/s41467-020-14323-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepatocyte nutrient sensing to regulation of glucose metabolism in mice.
