Nature Communications (Apr 2021)
Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s disease
- Angela M. Crist,
- Kelly M. Hinkle,
- Xue Wang,
- Christina M. Moloney,
- Billie J. Matchett,
- Sydney A. Labuzan,
- Isabelle Frankenhauser,
- Nkem O. Azu,
- Amanda M. Liesinger,
- Elizabeth R. Lesser,
- Daniel J. Serie,
- Zachary S. Quicksall,
- Tulsi A. Patel,
- Troy P. Carnwath,
- Michael DeTure,
- Xiaojia Tang,
- Ronald C. Petersen,
- Ranjan Duara,
- Neill R. Graff-Radford,
- Mariet Allen,
- Minerva M. Carrasquillo,
- Hu Li,
- Owen A. Ross,
- Nilüfer Ertekin-Taner,
- Dennis W. Dickson,
- Yan W. Asmann,
- Rickey E. Carter,
- Melissa E. Murray
Affiliations
- Angela M. Crist
- Department of Neuroscience, Mayo Clinic
- Kelly M. Hinkle
- Department of Neuroscience, Mayo Clinic
- Xue Wang
- Department of Health Sciences Research, Mayo Clinic
- Christina M. Moloney
- Department of Neuroscience, Mayo Clinic
- Billie J. Matchett
- Department of Neuroscience, Mayo Clinic
- Sydney A. Labuzan
- Department of Neuroscience, Mayo Clinic
- Isabelle Frankenhauser
- Department of Neuroscience, Mayo Clinic
- Nkem O. Azu
- Department of Neuroscience, Mayo Clinic
- Amanda M. Liesinger
- Department of Neuroscience, Mayo Clinic
- Elizabeth R. Lesser
- Department of Health Sciences Research, Mayo Clinic
- Daniel J. Serie
- Department of Health Sciences Research, Mayo Clinic
- Zachary S. Quicksall
- Department of Health Sciences Research, Mayo Clinic
- Tulsi A. Patel
- Department of Neuroscience, Mayo Clinic
- Troy P. Carnwath
- Department of Neuroscience, Mayo Clinic
- Michael DeTure
- Department of Neuroscience, Mayo Clinic
- Xiaojia Tang
- Department of Health Sciences Research, Mayo Clinic
- Ronald C. Petersen
- Department of Neurology, Mayo Clinic
- Ranjan Duara
- Wien Center for Alzheimer’s Disease and Memory Disorders, Mount Sinai Medical Center
- Neill R. Graff-Radford
- Department of Neurology, Mayo Clinic
- Mariet Allen
- Department of Neuroscience, Mayo Clinic
- Minerva M. Carrasquillo
- Department of Neuroscience, Mayo Clinic
- Hu Li
- Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic
- Owen A. Ross
- Department of Neuroscience, Mayo Clinic
- Nilüfer Ertekin-Taner
- Department of Neuroscience, Mayo Clinic
- Dennis W. Dickson
- Department of Neuroscience, Mayo Clinic
- Yan W. Asmann
- Department of Health Sciences Research, Mayo Clinic
- Rickey E. Carter
- Department of Health Sciences Research, Mayo Clinic
- Melissa E. Murray
- Department of Neuroscience, Mayo Clinic
- DOI
- https://doi.org/10.1038/s41467-021-22399-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Alzheimer’s disease (AD) is typically associated with hippocampal and cortical pathology, although hippocampal sparing and limbic predominant forms exist. The authors use transcriptomic analysis and neuropathology to identify genes associated with selective hippocampal vulnerability in AD.
